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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NAE1
All Species:
41.82
Human Site:
Y221
Identified Species:
70.77
UniProt:
Q13564
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13564
NP_001018169.1
534
60246
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
S
E
Chimpanzee
Pan troglodytes
XP_001159531
534
60179
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
S
E
Rhesus Macaque
Macaca mulatta
XP_001085059
534
60247
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
S
E
Dog
Lupus familis
XP_852003
534
60357
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8VBW6
534
60255
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
N
E
Rat
Rattus norvegicus
Q9Z1A5
534
60364
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505632
525
59197
Y212
W
I
V
I
L
A
K
Y
L
D
Q
W
T
R
E
Chicken
Gallus gallus
Q5ZIE6
535
60465
Y222
W
I
V
I
V
A
K
Y
L
T
K
W
F
N
E
Frog
Xenopus laevis
Q6NTW6
533
60607
Y220
W
I
I
V
V
A
K
Y
L
D
K
W
R
S
E
Zebra Danio
Brachydanio rerio
Q7SXP2
533
60386
Y220
W
I
I
V
V
A
R
Y
L
E
K
W
Y
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTE9
524
58698
Y219
W
L
L
V
L
H
K
Y
L
N
V
W
Q
K
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18217
541
60764
A218
Y
I
L
L
H
F
K
A
L
E
V
F
R
K
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42744
540
60016
K232
P
Y
V
V
I
L
V
K
M
A
E
E
W
A
Q
Baker's Yeast
Sacchar. cerevisiae
Q12059
462
52834
F192
S
K
M
D
T
A
T
F
S
G
I
P
Y
T
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.4
97.7
N.A.
97
96.8
N.A.
82.7
83.9
78.8
73
N.A.
45.1
N.A.
37.7
N.A.
Protein Similarity:
100
99.6
99.4
98.8
N.A.
98.6
98.3
N.A.
91.1
93
89.6
85.9
N.A.
64.2
N.A.
55.4
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
73.3
66.6
60
53.3
N.A.
33.3
N.A.
20
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
93.3
86.6
93.3
N.A.
66.6
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.8
25.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.7
46.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
79
0
8
0
50
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
15
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
15
8
8
0
0
72
% E
% Phe:
0
0
0
0
0
8
0
8
0
0
0
8
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
79
15
58
50
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
79
8
0
0
22
0
0
15
0
% K
% Leu:
0
8
15
8
15
8
0
0
86
0
0
0
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
22
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
50
0
8
0
22
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
15
8
0
% R
% Ser:
8
0
0
0
0
0
0
0
8
0
0
0
0
43
0
% S
% Thr:
0
0
0
0
8
0
8
0
0
8
0
0
8
8
0
% T
% Val:
0
0
65
29
22
0
8
0
0
0
15
0
0
0
8
% V
% Trp:
79
0
0
0
0
0
0
0
0
0
0
79
8
0
0
% W
% Tyr:
8
8
0
0
0
0
0
79
0
0
0
0
58
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _